knee cartilage regeneration

Fat-Derived Stem Cells vs Bone Marrow – Achieving Cartilage Regeneration

Scott Brandt, M.D. Research, Stem Cell Therapy, Stem Cells for Back Pain, Stem Cells for Joint & Soft Tissue Pain

Based on previous studies and our clinical experience, ThriveMD has built our stem cell therapy procedure based on the use of mesenchymal stem cells (MSC’s) prepared from adipose tissue (fat). The mixture of regenerative cells and growth factors that are derived from adipose tissue is called the stromal vascular fraction (SVF) and has been an excellent choice for soft tissue repair, especially the regeneration of cartilaginous joints such as knees, hips and shoulders.

Fat tissue provides the largest volume of adult stem cells, while bone marrow provides growth factors to aid with the repair process. That’s why we add bone marrow to our stem cell therapy formula as well.

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Contact our Vail or Denver office to find out if you could be a candidate for stem cell therapy.

The Potential of Cartilage Regeneration with Stem Cells

Such cartilage regeneration can have the potential to help avoid invasive procedures such as joint replacement, or alleviate pain in joints that have been arthritic for years.
Cartilage regeneration with stem cells can, for instance, have the potential to help avoid invasive procedures such as joint replacement, or alleviate pain in joints that have been arthritic for years. Throughout the past two years we have also been seeing excellent results with the use of SVF in the back pain treatment of, for instance, degenerative disc disease. Spinal applications of these therapies are quickly becoming the most successful stem cell procedure we perform at ThriveMD.

The Stem Cell Studies on Fat vs Bone Marrow

First, a recent stem cell research article by Jang and Koh titled Characterization of Adipose Tissue-Derived Stromal Vascular Fraction for Clinical Application to Cartilage Regeneration highly supports the premise that adipose derived cells are a far better source of stem cells than bone marrow concentrate (BMC) for a point of care (same day) cartilage regeneration stem cell procedure. This article did an excellent multi-part analysis comparing bone marrow concentrate to stromal vascular fraction (SVF) and cleared some stem cell misconceptions.

The authors used several types of analysis to define the significant differences in the content and function of these two regenerative injection concentrates. Flow cytometry allowed a thorough look at the cell yield. It demonstrated that SVF contained 10 times more MSC’s and 5 times more adherent cells than BMC, perhaps the most crucial components for these types of procedures .

It also showed that SVF had 200 times more stromal cells and 18 times more pericytes, both also very important in a regenerative procedure for joints and soft tissue. Also of importance, the BMC contained 6 times more leukocytes, or white blood cells which can impede healing by furthering the inflammatory reaction at the site of the injury.

One minute with Dr. Brandt on the best sources for harvesting stem cells

Stromal vascular fraction was dramatically better than bone marrow concentrate in its ability to differentiate into cartilage.
Two other important features were also well documented. SVF created significantly more colony forming units than BMC, another significant predictor of healing response. And perhaps most importantly, SVF was dramatically better than BMC in its ability to differentiate into cartilage.

Second, a recent study by Han Chao et al has also demonstrated that fat derived stem cells also have a higher proliferation potential for neural tissue and are a better source for not only cartilage regeneration but also for nervous system regeneration.

How the Different Types of Stem Cells Work to Regenerate Cartilage

Adipose fat tissue provides the largest volume of adult stem cells (1,000 to 2,000 times the number of cells per volume found in bone marrow). Bone marrow provides some stem cells but more importantly provides a large volume of growth factors to aid in the repair process. In addition to adult stem cells, fat tissue also contains numerous other regenerative cells that are important to the healing process. Stem cells derived from adipose fat tissue have been shown to be a much better source for the repair of cartilage degeneration and recent studies have demonstrated its superior ability to differentiate into cartilage.

Stem Cells from Fat vs Bone Marrow – the Superior Way to Harvest

The studies gavce a very comprehensive look at comparing BMC and SVF in the ability to repair cartilage damage in a same procedure protocol. Every significant measurement comparing bone marrow to adipose tissue for stem cell harvesting demonstrated that adipose provided better cell content and superior ability to differentiate into cartilage than bone marrow. Our extensive clinical experience with the procedure for Colorado patients clearly indicates the same.

*Individual patient results may vary. Contact us today to find out if stem cell therapy may be able to help you.

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If you believe you or someone you care about could be a candidate for stem cell therapy, please contact us today.

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John Beeman
John Beeman
23:05 08 Jan 17
I just wanted to give an update regarding the stem cell procedure performed by Dr. Brandt at Thrive about 3 years ago. My range of motion continues to improve--remarkable at 64.I skied 150k in 5 days last week and never iced my knee once. I can't remember skiing that many feet w/out having to ice in the last 20 years. The knee treated has been without an acl since I was 18 and is pretty severely arthritic,but I am getting better performance now than I have in recent memory. Thank you, Dr. Brandt!!
Laurel Wilkerson
Laurel Wilkerson
21:22 08 Aug 16
Great job by the Thrive MD team in Edwards. With a torn achilles tendon, I was really opposed to surgery. When I discovered Dr. Brandt and team, I was thrilled. They are most professional and explained every step of the process and procedure for treatment options. I am on the road to recovery, and I am so thankful to have discovered Thrive. Before you let an orthopedic doc operate, take the time to explore and discuss stem cell therapy. Thrive MD made the process easy and convenient. Thanks! One year later update - ankle is doing great. Skied 52 days in 2015-16. Hiking, biking and all are no problem. Great team of caring people who know their business.
Lisa Harris
Lisa Harris
15:59 02 Jan 17
After struggling with an Achilles injury for 1 1/2 years and trying everything to heal it - steroid, physical therapy, wearing a boot, no activity, stretching, etc - I decided to have stem cell therapy at Thrive.md. It was a short procedure and an afternoon of post op recovery, which after 6-8 weeks, resulted in a full recovery from my injury. This seemed to finally stimulate blood flow and healing to an injury I had resigned myself to having forever. I highly recommend this procedure for tendon injuries like this one.
John Reilly
John Reilly
13:44 04 Nov 16
I saw Dr Brandt on 8/8/16 for a lower back stem cell injection. From the injection, I got a serious infection in my lower spine. As a result, I spent 2 days in the Vail hospital and have been on daily IV antibiotics for the past 8 weeks. A few weeks after the injection, I started feeling increased pain which was a different pain than before my injection. It was much sharper and a shooting pain. I communicated this information to Dr Brandt and his staff. There only response and treatment was stronger pain meds. oral and injected steroids (the worst thing to do when an infection is present). The pain became so intense and debilitating, I finally made an appointment with an orthopedic surgeon. Their team quickly discovered from listening to my symptoms and reviewing a new MRI that I had an infection. I also discovered from a search on DORA that over the past 13 years Dr Brandt's has a history of incidents with the DORA which regulates medical professionals. Over this time, his license was suspended for a period of time and is he currently practicing on probation through 2019. At one point, the AG said he was unfit to practice medicine.
Zvezdomir Zamfirov
Zvezdomir Zamfirov
03:55 14 Nov 16
I am a pain management physician myself. I am 52, and physically very active. I still play soccer competitively. Six months ago I suffered a hip injury with a labrum tear. Due to the pre-existing wear and tear, the only conventional treatment, which was offered to me was total hip replacement. I wanted to remain physically active and continue to play sports, so I decided that this is not the best option for me. I choose instead to try stem-cell therapy. Ten days ago I had my procedure done by Dr. Brandt, and since then I have nothing but positive things to say about him and his practice. Everyone in his office was extremely welcoming and put me at ease and comfort about my procedure. The procedure went very smooth. And I did not have ANY post procedure pain or discomfort. I had no need for any pain medication. I was back to work seeing patients on the 2nd day after the procedure. My hip already feels noticeably better. I have the second procedure scheduled in four weeks, and I am confident that in another 3-4 weeks I'll be back playing soccer again. Thank you, Dr. Brandt and team for taking such excellent care of me.
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